重庆渝东南地区男性体检人群非酒精性脂肪肝检出情况及相关分析

Analysis of non-alcoholic fatty liver disease and the related factors among male population in Southeast Chongqing

摘要:

目的： 分析重庆市渝东南地区健康体检人群中成年男性非酒精性脂肪肝（non-alcoholic fatty liver disease，NAFLD）的检出情况及影响因素，为NAFLD的防治提供参考。方法： 选取重庆市黔江中心医院体检中心健康体检的16 792例男性体检者作为研究对象，对其资料进行回顾性分析。计算NAFLD检出率并采用单因素和多因素logistic回归分析NAFLD的相关危险因素。结果： 研究对象中NAFLD患者3 441例，检出率20.5％；51～60岁年龄组检出率最高，为29.4%。NAFLD组体质指数（body mass index，BMI）、总胆固醇（total cholesterol，TC）、甘油三脂（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）、空腹血糖（fasting blood glucose，FBG）、收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）、谷丙转氨酶（alanine transaminase，ALT）的均值水平明显高于非NAFLD组（P<0.01），高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）水平明显低于非脂肪肝组（P<0.01）；多因素logistic 回归分析结果提示，年龄、BMI、高血压，甘油三酯、ALT是NAFLD的独立危险因素（P<0.01）。结论： 重庆市渝东南地区男性体检人群中非酒精性脂肪肝检出率较高，51～60 岁年龄段最高；对肥胖、高血压、甘油三酯及ALT偏高人群应该重点进行NAFLD超声筛查，以便疾病的防治。

Abstract:

Objective: To investigate and analyze the detection rate and influencing factors of non-alcoholic fatty liver disease (NAFLD) in adult male healthy subjects in Southeast Chongqing, and to provide reference for the prevention and treatment of NAFLD. Methods: A total of 16 792 men who underwent physical examination in the physical examination center of a grade three hospital in Southeast Chongqing were selected as the research objects, and their data were retrospectively analyzed. The detection rate of NAFLD was calculated and the related risk factors of NAFLD were analyzed by univariate and multivariate Logistic regression. Results: Among the subjects, 3 441 were NAFLD patients, with the detection rate of 20.5%, and the detection rate was highest in 51 to 60 years old group (29.4%). The mean levels of body mass index (BMI), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and alanine transaminase (ALT) in NAFLD group were significantly higher than those in non-NAFLD group (P<0.01) and high density lipoprotein cholesterol (HDL-C) was significantly lower than that in non-NAFLD group (P<0.01). Multivariate Logistic regression analysis showed that age, BMI, hypertension, triglyceride and ALT were independent risk factors for NAFLD (P<0.01). Conclusion: The detection rate of nonalcoholic fatty liver disease in male population in Southeast Chongqing is relatively high, with the highest onset among 51-60 years old group. Ultrasound screening of NAFLD should be focused on those with obesity, hypertension, and rised triglyceride and ALT levels for the prevention and treatment of NAFLD.