巨噬细胞亚型与破骨细胞形成关系的研究进展

Research progress on the link between macrophage subtypes and osteoclast formation

摘要:

免疫系统参与骨再生并在其中发挥重要作用。巨噬细胞作为免疫系统重要组成部分，具有高度可塑性，可以根据微环境变化向M1和M2亚型极化。近年来破骨细胞在骨再生中的作用逐渐受到重视，而巨噬细胞为破骨细胞前体细胞，通过巨噬细胞-破骨细胞轴在骨再生中发挥重要作用。哪一种亚型巨噬细胞更易融合形成破骨细胞目前仍存在争议。本文就近年来巨噬细胞极化亚型M1、M2与破骨细胞形成关系相关研究进展进行综述，旨在为后期相关研究提供全面依据及更全面的认知。

Abstract:

Immune system plays critical roles in bone regeneration. Macrophages， as an important component of the immune system， are highly plastic and can polarize to M1 and M2 subtypes depending on microenvironmental changes. Recently， the role of osteoclasts in bone regeneration has gradually gained attention. Although macrophages are precursors of osteoclasts that play an important role in bone regeneration through the macrophage-osteoclast axis， it is still controversial that which subtype of macrophages is more likely to fuse to form osteoclasts. In this paper， we have reviewed the recent research progress related to the relationship between macrophage subtypes and osteoclast formation， aiming to provide a comprehensive basis and more comprehensive knowledge for further research.