糖尿病肾病相关基因多态性的研究进展

Research progress of related gene polymorphism of diabetic nephropathy

摘要:

糖尿病肾病（diabetic kidney disease，DKD）的发病机制尚未完全清楚。近年来，随着基因测序手段的发展，越来越多证据显示DKD可能是遗传和环境相互作用的结果。了解基因多态性与糖尿病肾病之间的关系，不仅有助于DKD的预防和诊断，也为设计研发新型药物提供新思路。本文就DKD与基因多态性之间的联系进行阐述。

Abstract:

Currently，the pathogenesis of diabetic kidney diseases（DKD） is not fully clear. In recent years，with the development of gene sequencing method，more and more evidence has proved that the DKD is probably the result of genetic and environmental interaction. To understand the relationship between gene polymorphism and diabetic nephropathy is not only conducive to the prevention and diagnosis of DKD，also helps to provide new way for the design research and development of new drugs. This paper elaborates the DKD and the connections between the gene polymorphism.