环状RNA在肿瘤代谢中的研究进展

Research progress of circular RNA in cancer metabolism

摘要:

由基因组不稳定引起的肿瘤代谢重编程被认为是肿瘤的一个独特标志，为癌细胞快速生长和增殖提供了必要的能量来源。环状RNA（circular RNA，circRNA）是一类具有闭合环状结构的非编码RNA，可以通过与其他RNA或蛋白质相互作用来影响蛋白水平发挥功能。越来越多的研究表明环状RNA参与肿瘤代谢重编程的调控，却很少关于环状RNA在肿瘤代谢中作用的综述。本文将系统阐述环状RNA与肿瘤代谢的关系，为临床癌症的诊断和治疗提供更好的理论依据。

Abstract:

Cancer metabolic reprogramming caused by genomic instability is considered to be a unique marker of tumor，providing a necessary energy source for the rapid growth and proliferation of cancer cells. Circular RNAs are a class of noncoding RNAs with a closed circular structure. They can function by interacting with other RNAs or proteins to affect the protein level. Recently，increasing studies have shown that circular RNAs are involved in the regulation of cancer metabolic reprogramming. However，there are few reviews on the role of circular RNAs in cancer metabolism. Therefore，in this paper，we will systematically elaborate the relationship between circular RNA and cancer metabolism， providing a better theoretical basis for the diagnosis and treatment of clinical cancer.