神经系统副肿瘤综合征临床诊断进展

Advances in clinical diagnosis of paraneoplastic neurological syndrome

摘要:

神经系统副肿瘤综合征（paraneoplastic neurological syndrome，PNS）是肿瘤通过远隔效应累及神经系统的一组罕见的免疫介导性疾病，其临床症状多样，通常伴有特异性的神经抗体。2021年，国际专家组修订了2004年PNS诊断标准，提出了新的临床评分系统，突出强调了“表型-抗体-肿瘤”的关联性。本研究回顾近年文献，围绕新标准，对PNS的临床诊断进展作一综述。

Abstract:

Paraneoplastic neurological syndromes（PNS） are a group of rare immune-mediated diseases in which tumors affect the nervous system through remote effects. Clinical symptoms are diverse and usually accompanied by specific neural antibodies. In 2021，the international expert group revised the 2004 version of the PNS diagnostic criteria，developed a new clinical scoring system， and highlighted the relationship between “phenotype-antibody-tumor”. This review aims to summarize the progress of the diagnosis of PNS， with a special focus on the new diagnostic criteria.