急性呼吸窘迫综合征内表型的研究进展

Research progress of subphenotype of acute respiratory distress syndrome

摘要:

急性呼吸窘迫综合征（acute respiratory distress syndrome，ARDS）是重症监护病房中一种常见的危重症疾病。由于对该疾病的认识尚且不足，其诊断及治疗仍充满挑战，病死率也一直居高不下。越来越多的学者认为ARDS在临床和生物学上都具有相当大的异质性，这引起不少学者的研究兴趣。本文旨在总结ARDS内表型的研究进展，以期为更好地认识其发病机制、为患者制定个性化治疗提供参考，促进ARDS的治疗早日迈向精准医学。

Abstract:

Acute respiratory distress syndrome（ARDS） is a common critical disease in intensive care unit. Due to insufficient understanding of the disease，its diagnosis and treatment are still challenging，and the mortality remains high. More and more scholars believe that ARDS has considerable heterogeneity in clinical and biological aspects，which has aroused the interest of many scholars. This article aims to summarize the research progress of the subphenotype of ARDS，so as to provide reference for better understanding of its pathogenesis，formulate individual treatment for patients， and promote the treatment of ARDS towards precision medicine as soon as possible.