铁死亡在阿尔茨海默病中的研究进展

Research advances of ferroptosis in Alzheimer's disease

摘要:

最新研究表明，铁死亡在阿尔茨海默病（Alzheimer's disease，AD）的发生发展中扮演重要角色。本文通过对近年相关国内外文献进行总结，对铁代谢紊乱、谷胱甘肽耗竭和脂质过氧化三种铁死亡主要机制与AD的关系进行分类综述，以期为AD的机制研究提供参考并提示铁死亡有望成为治疗AD的新策略。

Abstract:

Recent studies have shown that ferroptosis plays an important role in the occurrence and development of Alzheimer's disease. This article summarizes relevant domestic and foreign literature in recent years，and categorizes and reviews the relationship between the three main mechanisms of ferroptosis，namely iron metabolism disorder，glutathione（GSH） depletion，and lipid peroxidation，and AD. This finding suggests that ferroptosis may become a new therapeutic strategy to treat and prevent AD in the future.