间充质干细胞外泌体对肺动脉高压治疗作用的研究进展

Research advances in the therapeutic effect of mesenchymal stem cell exosomes on pulmonary hypertension

摘要:

肺动脉高压（pulmonary hypertension，PH）是一种以进行性肺血管收缩、肺血管重构、右心室肥厚为特征，进而导致右心衰竭的疾病。目前治疗PH的方法仍存在很多不足，需要寻找新的治疗策略。近年来，有关间充质干细胞（mesenchymal stem cells，MSC）对PH的治疗作用及机制研究相继被国内外许多学者所重视，成为PH细胞治疗的研究热点之一。其中，MSC的旁分泌机制被认为起到一个重要的治疗作用。从MSC中分离出的外泌体（exosomes，EXO）具有抑制肺血管重构的潜力，被认为是治疗PH的一种新的潜在治疗方法。本文就MSC外泌体在PH治疗中的作用及可能机制做一综述，从而为MSC的 EXO治疗PH提供理论依据。

Abstract:

Pulmonary hypertension（PH） is a disease characterized by progressive pulmonary vasoconstriction， pulmonary vascular remodeling，and right ventricular hypertrophy，finally leading to right heart failure. At present，there are still insufficiencies in the treatment methods for PH， and it is needed to develop new treatment strategies. In recent years，studies have been conducted on the therapeutic effect of mesenchymal stem cells（MSC） on PH and related mechanisms by scholars in China and globally，which has become one of the research hotspots of cell therapy for PH，and among them，the paracrine mechanism of MSC is considered to have an important therapeutic effect. Exosomes（EXO） isolated from MSC have the potential to inhibit pulmonary vascular remodeling and are considered as a new potential treatment method for PH. This article reviews the role and possible mechanism of MSC EXO in the treatment of PH，so as to provide a theoretical basis for the treatment of PH by MSC EXO in the future.