生物标志物炎症因子、细胞焦亡因子和铁死亡因子在膀胱癌治疗与预后中的价值

Value of inflammatory，pyroptosis，and ferroptosis biomarkers in the treatment and prognosis of bladder cancer

摘要:

根据2020年全球癌症统计，膀胱癌（bladder cancer，BC）是全球诊断率第十高的癌症，是男性第六常见的癌症和第九大癌症死因。尽管膀胱癌的确切原因尚不清楚，但已经确定了一些因素与膀胱癌风险增加相关，如吸烟、化学物质暴露、年龄、性别、遗传因素、环境因素等。BC会导致疼痛、尿路感染、尿失禁和死亡等，对患者的健康情况及经济造成巨大的影响。为了更好地预防和治疗BC，生物标志物的检测可以被用来监测或预测BC的存在、进展或治疗效果。近年来，研究表明，BC的发展与炎症、细胞焦亡、铁死亡等分子机制密切相关。越来越多的研究也关注到这些分子机制相关的生物标志物在BC中的应用。本综述将探讨这些新型生物标志物在BC诊断、治疗与预后中的价值，为进一步在膀胱癌治疗的不同阶段有针对性地靶向上述分子，以达到控制疾病、延长无病间期、抑制肿瘤复发和转移的目的。

Abstract:

According to Global Cancer Statistics 2020，bladder cancer is the tenth most commonly diagnosed cancer worldwide，which is the sixth most common cancer and the ninth leading cause of cancer-related death in men. Although the exact pathogenesis of bladder cancer is unclear，certain factors have been demonstrated to be associated with an increased risk of bladder cancer，such as smoking，chemical exposure，age，sex，genetic factors，and environmental factors. Bladder cancer can cause pain，urinary tract infection，urinary incontinence，and death，which can impose a huge health and economic burden on patients. To better prevent and treat bladder cancer，the detection of biomarkers can help monitor or predict the development，progression，or treatment of bladder cancer. In recent years，studies have shown that the development of bladder cancer is closely related to various mechanisms including inflammation，pyroptosis，and ferroptosis，and these molecular mechanisms-related biomarkers have been increasingly applied in the research of bladder cancer. This review focuses on the value of these novel biomarkers in the diagnosis，treatment，and prognosis of bladder cancer，which can be potential targets at different treatment stages of bladder cancer for controlling the disease，prolonging disease-free interval，and inhibiting tumor recurrence and metastasis.