鞍区占位性疾病与性激素替代治疗

Sellar space-occupying diseases and sex hormone replacement therapy

摘要:

中枢性获得性性腺功能减退病因较多，其中鞍区占位性疾病是重要原因。性腺激素替代治疗可以恢复性功能、改善代谢、提高生活质量和增强自信心。本文将鞍区占位性疾病分为雌激素受体阳性或者雌激素相关肿瘤、雌激素受体阴性或者不明确的肿瘤、非肿瘤性鞍区占位性疾病3类。就鞍区各种类型占位性疾病及其治疗干预对性腺功能的影响，以及不同情况下性激素替代治疗的注意事项进行文献回顾，以期为该类疾患患者治疗提供意见和帮助。同时，也就目前一些问题提出思考，召唤更多的临床观察和基础研究进一步完善鞍区占位性疾病患者的性激素替代治疗策略。

Abstract:

There are many causes of acquired central hypogonadism，among which sellar space-occupying diseases are important factors. Gonadal hormone replacement therapy can restore sexual function，improve metabolism and quality of life，and enhance self-confidence. In this study，sellar space-occupying diseases are classified into three categories；estrogen receptor-positive or estrogen-related tumors，estrogen receptor-negative or ambiguous tumors，and non-tumoral sellar space-occupying diseases. This article reviews each type of sellar space-occupying diseases，the influence of treatment interventions on gonadal function，and the precautions for sex hormone replacement therapy under different circumstances，in order to provide advice and help for the treatment of patients with such diseases. Meanwhile，this article also puts forward thoughts on several issues at present and calls for more clinical observation studies and basic researches to further improve sex hormone replacement therapy for patients with sellar space-occupying diseases.