单核细胞/淋巴细胞比值与糖尿病足患者下肢动脉病变的相关性研究

Relationship between monocyte-to-lymphocyte ratio and lower extremity arterial disease in patients with diabetic foot disease

摘要:

目的 探讨单核细胞/淋巴细胞比值（monocytes to lymphocytes ratio，MLR）与糖尿病足患者下肢动脉病变（lower extremity arterial disease，LEAD）的相关性。方法 选取2020年4月至2023年4月于陆军军医大学第一附属医院住院治疗的2 型糖尿病足患者243例，分为下肢动脉病变组（LEAD，n=103）和非下肢动脉病变组（non-lower extremity arterial disease，NLEAD，n=140），分析MLR与LEAD的相关性。结果 LEAD组MLR显著高于NLEAD组［0.46（0.29，0.63） vs. 0.38（0.26，0.58）（P<0.05）］。logistic回归分析结果显示，MLR、年龄、胆固醇、血肌酐是糖尿病足患者发生下肢血管病变的影响因素（P<0.05）。受试者工作特征曲线分析表明，MLR预测糖尿病足患者下肢血管病变的最佳切点为0.34，敏感度和特异度分别为69.9%和46.4%。结论 MLR与2型糖尿病足患者LEAD的发生相关。

Abstract:

Objective To evaluate the relationship between the monocyte-to-lymphocyte ratio（MLR） and lower extremity arterial disease（LEAD） in patients with diabetic foot disease.Methods We included a total of 243 patients with type 2 diabetic foot problems hospitalized in The First Affiliated Hospital of Army Medical University from April 2020 to April 2023. They were divided into LEAD group（n=103） and non-LEAD group（n=140） to analyze the relationship between MLR and LEAD.Results The MLR in the LEAD group was significantly higher than that in the non-LEAD group（0.46［0.29，0.63］ vs. 0.38［0.26，0.58］，P<0.05）. The logistic regression analysis showed that MLR，age，serum cholesterol，and serum creatinine were risk factors for LEAD in patients with diabetic foot disease（P<0.05）. The receiver operating characteristic curve analysis showed that the optimal cut-off point for MLR predicting lower extremity arterial disease in patients with diabetic foot problems was 0.34，with sensitivity and specificity being 69.9% and 46.4%，respectively.Conclusion MLR is associated with the development of LEAD in patients with type 2 diabetic foot disease.