DYRK2在肿瘤发生发展及预后中的研究进展

Research progress of DYRK2 in tumor occurrence，development， and prognosis

摘要:

双特异性酪氨酸磷酸化调节激酶2（dual-specificity tyrosine-phosphorylation-regulated kinase 2，DYRK2）属于DYRK家族，是真核生物中一种进化保守的酶。DYRK2在不同组织及肿瘤中的表达具有较大差异。既往关于DYRK2在肿瘤中的作用报道表明DYRK2通过延长G₁期、促进细胞凋亡及抑制上皮-间充质转化来延缓肿瘤生长。近年来研究发现DYRK2亦可通过促进细胞有丝分裂、抗肿瘤凋亡、促进细胞侵袭、迁移及增强耐药而发挥促癌作用。本文就DYRK2的结构、功能及其在肿瘤发生发展中的作用及预后价值进行综述。

Abstract:

Dual-specificity tyrosine-phosphorylation-regulated kinase 2（DYRK2） belongs to the DYRK family and is an evolutionarily conserved enzyme in eukaryotes. The expression of DYRK2 varies greatly in different tissues and tumors. Previous reports on the role of DYRK2 in tumors have shown that it can delay tumor growth by prolonging G₁ phase，promoting apoptosis，and inhibiting epithelial-mesenchymal transition. Recent studies have found that DYRK2 can also play a cancer-promoting role by enhancing cell mitosis，tumor apoptosis resistance，cell invasion and migration，and drug resistance. Here we present a review of the structure and function of DYRK2 as well as its roles in tumor occurrence，development，and prognosis.