机械应力影响细胞焦亡的机制研究进展

Research progress on the mechanisms of mechanical stress affecting cell pyroptosis

摘要:

细胞焦亡是一种由炎性小体传感器激活引起的细胞死亡，最终导致细胞膜的完整性丧失。细胞焦亡导致其胞内容物泄漏至胞外空间诱导趋化和炎症，因此在炎症和疾病的发生发展中具有重要作用。细胞长期处在复杂的机械环境中，机械刺激可来源于微环境，也可来自外力。适宜的机械应力有助于细胞正常生理活动的进行，但过度的机械应力会激活应激信号通路，如死亡通路，从而引起细胞组织损伤和炎症反应，因此本文就细胞焦亡的分子机制及机械应力影响细胞焦亡的具体机制进行文献回顾及综述，旨在为研究焦亡相关疾病提供依据。

Abstract:

Pyroptosis is a type of cell death that culminates in the loss of membrane integrity as a result of the activation of inflammasome sensors. Pyroptosis plays an important role in the development and progression of inflammation and diseases because of a leakage of the cellular contents into the extracellular space. Cells live in a complex mechanical environment and are subject to various mechanical stimuli originating from the microenvironment and external forces. Appropriate mechanical stress contributes to the normal physiological process of cells，but excessive mechanical stress can activate stress signaling pathways，such as death pathways，resulting in cell tissue damage and inflammation. In this paper，we review the literature on the molecular mechanisms of cell pyroptosis and how mechanical stress affects cell pyroptosis，aiming to provide a basis for future research on pyroptosis-related diseases.