血浆炎性因子吸附在脓毒症治疗中的应用研究进展

Research progress of plasma inflammatory cytokine adsorption in the treatment of sepsis

摘要:

脓毒症和脓毒性休克是重症监护室常见病种，全球每年有超过1 800万严重脓毒症病例。国外流行病学调查显示，脓毒症的病死率已经超过心肌梗死，成为重症监护室非心脏病人的死亡主要原因。医学的进步带来越来越多治疗脓毒症的创新治疗方式，连续血液净化逐渐成为脓毒症患者早期治疗的重要手段，同时体外血液吸附在脓毒症患者中的治疗价值也逐渐受到重视。本文旨在总结近些年血浆炎性因子吸附在脓毒症治疗中应用的研究进展，对现有研究报道或已在临床应用的常见的几种体外血液吸附技术及其相关研究进展进行总结，以期为更好认识其在临床治疗中的运用价值及对预后的改善提供参考，从而为脓毒症及脓毒症休克患者治疗提供帮助。

Abstract:

Sepsis and septic shock are common in intensive care units，with more than 18 million cases of severe sepsis worldwide each year. According to the epidemiological survey abroad，the case fatality rate of sepsis has exceeded that of myocardial infarction， so sepsis has become the main cause of death of non-cardiac patients in intensive care units. Medical advances have led to more and more innovative treatments for sepsis. Continuous blood purification is gradually emerging as a crucial early treatment modality for septic patients，while extracorporeal blood adsorption is also gaining attention for its therapeutic value in septic patients. This article aims to summarize the research progress of plasma inflammatory cytokine adsorption in the treatment of sepsis in recent years， as well as the common extracorporeal blood adsorption techniques that have been reported in existing research or applied clinically along with their research advances，thus providing a reference for better understanding its application value in clinical treatment and improving the prognosis，and offering help for the treatment of patients with sepsis and septic shock.