L型钙离子通道α1C亚基基因多态性与精神分裂症的Meta分析

Meta analysis on the relationship between gene CACNA1C polymorphism and schizophrenia

摘要:

目的：用Meta分析的方法综合评价L型钙离子通道α1C亚基基因（calcium channel，voltage-dependent，L type，alpha1C subunit gene，CACNA１C）多态性位点与精神分裂症（schizophrenia，SCZ）的关系，为SCZ的遗传背景提供询证医学证据。方法：通过计算机对PubMed、中国生物医学文献光盘数据库（CBMdisc）数据库进行检索（2000年1月至2013年11月）。根据纳入标准收集CACNA１C多态性位点与SCZ病例对照研究的国内外全文文献。应用RevMan 5.1软件对符合条件的研究结果进行Meta分析，包括异质性检验，OR值以及评估发表偏倚。结果：共5篇外文文献符合条件并纳入分析，累计精SCZ组3 555例，健康对照组19 566例。数据合并结果显示，CACNA１C多态性位点rs1006737A型基因与SCZ有关联。按种族分为高加索亚组和亚洲亚组进行分析，组内无显著异质性，G/A+A/A vs. G/G基因型合并OR=1.16（95%CI=1.03~1.31）和1.29（95%CI=1.10~1.52），总效应测定结果Z=2.39、3.09（均P＜0.05）。结论：CACNA１C多态性位点rs1006737 A型基因与SCZ有明显关联，且与高加索人和亚洲人群SCZ易感性相关，携带A型基因可能增加SCZ的患病风险。

Abstract:

Objective：To assess the associations of Calcium channel，voltage-dependent，L type，alpha1C subunit gene（CACNAIC）gene polymorphism with schizophrenia by Meta analysis and to provide evidence-based medicine references for the genetic back－ground of schizophrenia. Methods：Literatures on the relationship between gene CACNA1C polymorphism rs1006737 and schizophre－nia both in PubMed and China Biology Medicine Databases were taken as research objects from January 2000 to November 2013. Statistical analysis was performed with RevMan 5.1 including the heterogeneity，odd ratio and evaluation on publication bias. Results：Five literatures meeting the criteria were included including 3 555 cases of schizophrenia and 19 566 cases of healthy controls. There was significant association between CACNA1C polymorphism rs1006737 and schizophrenia. The subgroups were Caucasian and Asian and there was no significant heterogeneity between subgroups. The summary OR for studies in Caucasian and Asian with the frequency of（G/A+A/A vs. G/G） genotype was 1.16（95%CI=1.03 to 1.31，Z=2.39） and 1.29（95%CI=1.10 to 1.52，Z=3.09），with significant differences（both P<0.05）. Conclusion：There is significant association between CACNA1C polymorphism rs1006737 A gene and schizophrenia. rs1006737 polymorphism may contribute to susceptibility of schizophrenia in Caucasian and Asian. CACNA1C polymorphism rs1006737 A gene may confer the risk of schizophrenia as an independent risk factor.