Abstract:Objective: To study the changes and diagnostic value of peripheral serological indexes in knee osteoarthritis. Methods: A total of 228 patients with knee osteoarthritis (KOA) admitted to our hospital undergoing total knee arthroplasty (TKA) from January 2013 to January 2018 and 120 healthy volunteers were enrolled in this study. They were divided into KOA group and healthy control group. Demographic parameters, blood neutrophil percentage (NEU%), monocyte count, lymphocyte count, red blood cell distribution width (RDW-CV), serum alkaline phosphatase (ALP), and serum uric acid (UA) of all participants were recorded, and the neutrophillymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) were calculated and compared between the two groups. Then the receiver operating curve (ROC) was drawn to determine the diagnostic threshold. The HSS scores of knee joint at 1 day, 3 months, 6 months and 1 year after TKA were followed up, and the correlation between HSS scores and NLR and MLR was analyzed. Results: Elevated blood NLR, MLR and RDW-CV were apparent features in KOA patients compared with healthy individuals (P<0.001) and NLR≥2.005, MLR≥0.165 and RDW-CV≥12.45 were the diagnostic thresholds for KOA based on the ROC characteristics. These blood indictors of only 26 patients with KOA were followed up for one year after TKA, and the results indicated that NLR and MLR were gradually reduced with the improvement of knee joint HSS scores, with significant correlation. Conclusion: Our present results show that both NLR, MLR and RDW-CV are promising peripheral blood markers of KOA, and the NLR and MLR may be served as the serum markers to predict the prognosis of TKA.
