Abstract:Objective: To investigate the expression of blood urea nitrogen in differentiated thyroid cancer and benign thyroid tumors, so as to evaluate the difference of urea cycle dysregulation between them. Methods: A total of 218 patients with diagnosis of differentiated thyroid cancer were enrolled in the group A and 193 patients with benign thyroid tumors in the group B. Blood urea nitrogen levels were measured 1-3 days before surgery.T test was used to analyze differences of urea nitrogen levels in two groups and two-way ANOVA analysis of variance was used to assess the effects of age, gender and tumor properties on urea nitrogen levels. The expression of genes related to urea cycle was evaluated by GEPIA database. Results: After excluding chronic lymphocytic thyroiditis, the urea nitrogen level in the group A was significantly higher than that in the group B (P>0.05). Males' age>55 years old was the factor for elevating nitrogen levels, while the metastasis status of lymph node was not an influencing factor. The expression of TP53 and MDM2 in the cancer tissue was higher, without significant differences. Conclusion: Males older than 55 years old are more likely to have dysregulation of urea metabolism.
