Abstract:Objective: To study the role of vancomycin plasma concentration determination in treating patients with peritoneal-dialysisrelated peritonitis, so as to provide theoretical basis for peritonitis treatment. Methods: Clinical data of patients with peritoneal-dialysisrelated peritonitis from January 1, 2016 to December 31, 2018 in our hospital were collected and retrospectively analyzed. Patients were divided into the low concentration group (<15 μg/mL) and the high concentration group (≥15 μg/mL) according to the blood concentration of vancomycin. Differences in gender, onset characteristics, age, dialysis age, various routine biochemical indicators, urine volume, dropout rate, body mass index (BMI) and hospitalization day between two groups were analyzed. Factors influencing the blood concentration of vancomycin were detcetd by logistic regression analysis. Results: A total of 106 cases of peritoneal dialysisrelated peritonitis occurred in the last three years, with an average incidence of 0.19 times/year. Among them, 72 cases (67.92%) were positive for bacteria culture of permeable bacteria, among which 39 strains (54.17%) were gram-positive bacteria. Among the grampositive bacteria, Staphylococcus epidermidis and Staphylococcus aureus were the most common, and were sensitive to vancomycin. BMI, urine volume, and hospitalization time between two groups had significant differences. Logistic regression analysis showed that low-density lipoprotein (OR=2.240, P=0.038), BMI (OR=1.981, P<0.001) and urine volume (OR=13.749, P=0.010) were the main factors affecting vancomycin concentration. Conclusion: The determination of vancomycin plasma concentration is of great clinical significance to provide a more reasonable drug regimen for treating peritoneal-dialysis-related peritonitis.
