Abstract:Objective: To investigate the influence of moderate-severe ovarian hyperstimulation syndrome (OHSS) on terminal singleton and twin pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods: A total of 260 patients underwent IVF-ET in our department from January 2008 to December 2015 were selected and clinical data and pregnancy outcome of 115 patients with moderate-severe OHSS were retrospectively analyzed. A total of 156 patients underwent IVF-ET according to age, cause of infertility and the number of mature oocytes, and did not develop OHSS within the fresh transplantation cycle were selected as the control group. According to the newborn amount, patients were divided into the singleton group and twin group, indicators including age, infertility duration, body mass index (BMI), basic of follicle-stimulation hornone (bFSH), total Gn amount, serum estradion (E2) on the day of human chorionic gonadotropin (HCG), the number of retrieved oocytes, 2PN number, high quality embryos, endometriai thickness on the day of embryo transfer, transferable embryos, gestational age of delivery, birth weight, preterm birth rate, cesarean section rate, small for gestation age infant (SGA), and morbidity of pregnancy complications (including, gestational diabetes mellitus, gestational hypertension, postpartum hemorrhage, placenta previa and placenta increta rate) between two groups were compared. Results: E2 level on the day of HCG and SGA rate in the singleton groupwere higher than that in the non OHSS group, with statistically significant difference (P=0.00, P=0.00). BMI in the OHSS group was lower than that in the non-OHSS group, with statistically significant difference (P=0.00). General data and pregnancy outcome in two groups had no significant differences. Conclusion: Moderate-severe OHSS can increase the risk of SGA in singleton pregnancy; moderate-severe OHSS has no obvious influence on terminal pregnancy outcome of twin pregnancy.
