Abstract:Objective: To investigate the recent and mid-term pulmonary function changes in neonates with congenital diaphragmatic hernia repair. Methods: From January 2009 to March 2016, the clinical data and follow-up data of postoperative pulmonary function of children who underwent congenital diaphragmatic hernia repair in our hospital were collected, and 27 valid reports were obtained. According to different lung function measurement methods, they were divided into infant group (aged 0-3 years, 12 cases were measured by tidal volume analysis and infant box test) and older children group (aged over 3 years, 15 cases were measured by mandatory breath measurement). Healthy infants (12 cases) aged 0 to 3 years were selected as the infant control group. Results: For the infant group, tPTEF% tE, VPEF% VE, Ratio tI to tE and TEF 25% were lower than those in the infant control group. For the older children group, FEV1/FVC, PEF and MEF75 of the children were within the normal range, but lower than the normal predicted values (P<0.01). Conclusion: Pulmonary function test shows obstructive lesions of the small airway in the neonates with congenital diaphragmatic hernia repair. The pulmonary function improves with the increase of age, and becomes normalized in older children, whereas there are some values still a little lower than predicted values.
