Abstract:Objective: To investigate the risk factors of adolescents with cancer and mental crisis status from the perspective of ecosystem theory, and to provide reference for constructing an intervention model of psychological crisis for adolescents with cancer. Methods: Adolescents aged 8-18 with cancer and some healthy children were included in this study, they were investigated on spot with depression anxiety stress scale 21 (DASS-21), and the questionnaire data were input twice and analyzed. The correlation degree and mutual influence of individual, family, environment, disease and other factors of children were analyzed from micro, meso, appearance and macro system of ecological system theory, so as to clarify the key influencing factors. Results: The investigation included in 218 adolescents with cancer, and 217 were analyzed. The detection rate of mental crisis was 45.6%, among which the detection rate of depression was 26.7%, the detection rate of anxiety was 45.6%, and the detection rate of stress was 24.4%. They were 12.5%, 13.5%, and 8.5% higher than those of health adolescents, respectively. Among the influencing factors, the detection rate of depression in male children was higher than that in female children, the detection rate of depression and stress in one-child children was higher than that in non-only children, the detection rate of depression and stress in children raised in authoritarian family was higher than that of children raised in democratic family, and the detection rate of anxiety in children with regular follow-up was higher than that of children not regularly followed up, with s statistical significance (P<0.05). The variables with P<0.05 were included in multivariate logistic analysis, and it was found that adolescents with cancer raised in authoritarian family had the highest risk of mental crisis. Conclusion: Adolescents with cancer have mental crisis such as anxiety, depression and stress, especially the one-child children and the children raised in authoritarian family. It's necessary for hospitals, families, schools, and the whole society to carry out preventive intervention in order to create a good ecosystem for these children, promoting their physical and mental health.