Abstract:Objective: To investigate influencing factors of the perceived effect of highly active antiretroviral therapy (HAART) in people living with HIV or AIDS (PLWH), and to provide scientific basis for the promotion of antiviral therapy. Methods: Retrospective survey was conducted in this study, and face-to-face questionnaire survey was used to collect general demographic information, basic knowledge of AIDS, medication status, medication adherence, and perceived effect of HAART. Chi-square test, rank sum test and ordered categorical variable logistic regression were used as statistical methods. Results: We collected complete information of 321 subjects, and the awareness rate of basic knowledge of AIDS was 88.16%. In the last year, 259 patients had been tested for HIV viral load, 258 of which had a viral load of<50 copies/mL, and the average CD4+T cell was (444.23±178.29) /μL for the last time.70.09% of PLWH perceived the therapeutic effect as "effective", and 6.23% of PLWH perceived the therapeutic effect as "very effective". Awareness of stopping or reducing drug taking while adverse reactions occurred (OR=0.337, 95%CI=0.178-0.638), the number of CD4+T cells before treatment (OR=2.931, 95%CI=1.479-5.807), duration of treatment (OR=0.438, 95%CI=0.230-0.835) had influence on perceived efficacy. Conclusion: HAART has a good therapeutic effect, but it's inconsistent with the perceived effect. Family support, medication compliance, knowledge of AIDS prevention, CD4+T cell level before treatment, and treatment time were associated with self-perceived efficacy. It's suggested to take comprehensive intervention measures such as psychological intervention and compliance education to improve the self-perceived effect of PLWH.
