Abstract:In the pathogenesis of ischemic stroke, due to the breakdown of blood-brain barrier structures such as endothelial cells, reperfusion injury, and coagulation dysfunction after thrombolytic therapy, etc., the restored blood flow enters the brain tissue from the damaged blood vessels, which is called hemorrhagic transformation (HT). Severe HT is one of the causes of death in patients. Researches find that HT may be related to many factors, such as venerable age, diabetes, and the severity of the patient's condition. It will be helpful for the prevention and treatment of clinical HT whether the probability of HT can be determined quantitatively by biological markers and reduced by management. Therefore, this paper reviews the advances in this area.
