Abstract:Objective: To assess the efficacy of transcranial sonography (TCS) on substantia nigra in Parkinson disease (PD) on the basis of Meta analysis. Methods: Studies about TCS from January 2010 to November 2019 in databases of PubMed, Embase, Cochrane library, CNKI, VIP and CBM were searched and collected. Two evaluators independently screened the literature, evaluated the quality of the literature and extracted relevant information according to inclusion and exclusion criteria. Meta-DiSc1.4 software was used to perform the Meta analysis, corresponding effect model was selected according to the heterogeneity results, effect size and 95% confidence interval (95%CI) were calculated, the receiver operator characteristic (ROC) curve was drawn, area under the curve (AUC) as well as Q value was calculated and Deek's funnel plot was drawn by adopting Stata 12.0 software to evaluate and publish bias. Results: A total of 753 literatures were retrieved and 28 literatures were finally included. Meta analysis results showed that the combined sensitivity of TCS in diagnosing PD was 0.82 (95%CI=0.80-0.83), the combined specificity was 0.90 (95%CI=0.88-0.91), the diagnostic odds ratio was 42.84 (95%CI=28.37-64.68), the positive likelihood radio was 7.46 (95%CI=6.11-9.11), the negative likelihood radio was 0.19 (95%CI=0.15-0.25), and SROC AUC and Q index were 0.947 0 and 0.886 5, respectively. Conclusion: As a new auxiliary examination method for neurological diseases, TCS has a high diagnostic value in the diagnosis of PD, non-invasive, radiation-free, economical and easy to operate, which can be promoted in the clinical as an early screening and auxiliary diagnostic tool for PD.
