Abstract:Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus, and it's also a common type of secondary chronic kidney disease (CKD) as well as the main cause of end stage renal failure. The specific pathogenesis of DKD is not well understood yet, which is related to many factors, and current research indicates that inflammation plays an important role in the development and progression of DKD. This review summarizes the role of relevant inflammatory molecules and signaling pathways in the progression of DKD. At the same time, we also have reviewed the beneficial effects of several drugs targeting cytokines, chemokines, transcription factors, kinases and molecules that promote the resolution of inflammation as well as several anti-inflammatory compounds on DKD. Therefore, the use of targeted drugs against these inflammatory factors, inflammatory signaling pathways and their downstream products as well as molecules that promote the resolution of inflammation to control inflammation may become a new approach and measure for DKD treatment in the future.
