Abstract:Objective: To investigate the therapeutic status and clinical curative effects of patients with locally advanced cervical cancer (LACC) who underwent neoadjuvant chemotherapy (NACT) before radiotherapy. Methods: Totally 150 cases of LACC (IB2-IVA) admitted to Chongqing University Cancer Hospital from January 2013 to December 2017 were collected in this study. All patients underwent NACT before radiotherapy. The therapeutic status and myelosuppression were evaluated, and the overall survival (OS) and progression-free survival (PFS) of 1 year and 3 years were analyzed. Results: The concurrent chemotherapy for 36 cases (24%) were not administered during radiotherapy, and 48 cases (42.11%) did not complete the full course of chemotherapy among patients receiving concurrent chemotherapy. The duration of radiotherapy for 55 cases (36.67%) were more than 56 days. The GradeⅢor higher myelosuppression were occurred in 71 patients (47.33%). The recent objective response rate (ORR) was 84.66%, but the complete response (CR) was only 25.33%. A total of 112 cases (74.67%) were given various forms of follow-up adjuvant therapy. The OS and PFS of 1 year and 3 years were 90.0% and 66.7%, and 66.7% and 46.7%, respectively. Conclusion: The NACT before radiotherapy for LACC patients reduces the tolerance to radiation therapy, prolongs the duration of radiotherapy, affects the implementation of concurrent chemotherapy, and the prognosis of LACC patients is not improved because the OS and PFS are not prolonged.
