Abstract:Objective: To analyze the prognostic relationship between Human papillomavirus (HPV) -infection and endocervical adenocarcinoma (ECA) of the uterine cervix, so as to provide a reference for clinical work. Methods: Clinical data of 468 ECA patients screened from SEER Database were divided into HPVA (HPV-associated adenocarcinoma) and NHPVA (non-HPV-associated Adenocarcinoma) group, followed by a retrospective analysis, which were statistically analyzed using Chi-square test, Fisher test, K-M method, log-rank test and Cox regression. Results: There were significant differences in stage and tumor differentiation grade between the two groups. Compared with HPVA group, the stage of NHPVA group was later (P=0.001), and the tumor differentiation was worse (P<0.05). The NHPVA group had a significantly higher cancer-related mortality (70/205, 34.1%) than HPVA group (53/263, 20.2%). The prognosis was significantly worse in NHPVA group than HPVA group (P=0.001). The cancer-related mortality was significantly different (P=0.002) within the 5 sub-groups of mucinous, gastic type, villoglandular, clear cell, and serous carcinoma, while the serous type had the worst prognosis. Conclusion: It is important to classify the ECA into HPVA and NHPVA for clinical work in the future.
