Abstract:Objective: To investigate the fasting blood-glucose (FBG) levels of middle-aged and elderly people in Chongqing, and analyze the risk factors related to impaired fasting glucose (IFG), so as to provide a basis for the prevention and control of diabetes. Methods: The middle-aged and elderly people undergoing health examination in a tertiary Grade-A hospital in Chongqing from January to December in 2019 were retrospectively analyzed. FBG and related physiological and biochemical data were collected. The dose-response relationship between IFG and body mass index (BMI) was analyzed using Logistic regression model combined with restricted cubic splines (RCS). Results: A total of 3 913 IFG cases were detected in 44 525 subjects, with a detection rate of 8.79%, of which the detection rate was 10.71%in males and 6.84%in females (P<0.001). The study subjects were divided into normal glucose tolerance (NGT) group and IFG group. The two groups had statistical differences in gender, age, BMI, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), triacylglycerol (TG), and uric acid (UA) (P<0.001). After adjusting for confounding factors, the relationship between overweight group (OR=1.178, 95%CI=1.074-1.293) and obesity group (OR=1.350, 95%CI=1.157-1.574) and IFG was statistically significant. RCS analysis showed that there was a nonlinear dose-response relationship between the continuous changes of BMI and IFG in males, 40-years old and 50-years old. Conclusion: Overweight and obesity are dose-dependent risk factors for IFG. As BMI increases, the risk of IFG increases.
