Abstract:Objective: To analyze the correlation between coagulation function and gestational age in early and middle-term premature infants, and to explore the risk factors and outcomes of abnormal coagulation in early postnatal period. Methods: The blood coagulation test results within 24 hours after birth and clinical data of 496 premature infants cases were retrospectively analyzed. The coagulation function parameters of these preterm infants with different gestational ages were compared, and the risk factors of abnormal coagula tion function and the relationship with intracranial hemorrhage were analyzed. Results: There were significant differences in activated partial thromboplastin time, fibrinogen and D-dimer (DD) between the two groups of preterm infants in early coagulation function parameters (P<0.05). Univariate analysis showed that the incidence of birth weight, intrauterine distress, hypertensive disorders pregnancy, meconium-stained amniotic fluid, patent ductus arteriosus (PDA), abnormal liver function and thrombocytopenia in preterm infants with abnormal coagulation function were higher than that in the normal group, with significant differences (P<0.05). Logistic regression analysis found that male, intrauterine distress, PDA and thrombocytopenia were independent risk factors. Compared with the intracranial non-bleeding group, the bleeding group had a more prolonged prothrombin time (PT) (P<0.05), and the severe group had a higher DD (P<0.05) when compared with the non-bleeding group and the mild group. Conclusion: The coagulation function of premature infants gradually matures with the increase of gestational age. Male, intrauterine distress, PDA and thrombocytopenia are risks factors of abnormal coagulation in preterm infants. PT prolongation may be related to the occurrence of intracranial hemorrhage, while DD is related to its severity.
