Clavien-Dindo/CTCAE classification grading and risk factors analysis of postoperative complications in early cervical cancer

Abstract:

Objective: To evaluate the postoperative complication of early cervical cancer and analyze its risk factors by using the Clavien-Dindo/CTCAE complications classification system. Methods: The clinical data of 412 patients with early cervical cancer from the our hospital from January 2008 to December 2015 were retrospectively analyzed, among which 54 were excluded without surgery, 23 did not meet the FIGO staging criteria, 60 clinical data were missed, and 27 withdrew from follow-up. Finally, a total of 248 patients with early cervical cancer were included. The patients were 44.5 (25, 85) years old and had a body mass index (BMI) of 22.9 (14.6, 45) kg/m². The system was used to grade patients during and after surgery. Univariate analysis of patient baseline data was performed. Variables with P<0.2 were included in the multivariate logistic regression model to determine risk factors for intraoperative and postoperative complications. Kaplan-Meier survival curve was used to analyze the overall survival rate and log-rank test was used. Results: There were 31 cases (14.1%) of severe complications (Clavien-Dindo/CTCAETC≥3), 120 cases (48.4%) of non-serious complications, and 97 (39.1%) of no complications. Multivariate logistic regression model showed that BMI>30 kg/m²was an independent risk factor for intraoperative complications (OR=4.90, 95%CI=1.72-20.44, P=0.020). The parauterine invasion (OR=7.39, 95%CI=1.37-39.72, P=0.020), and preoperative radiotherapy (OR=3.98, 95%CI=1.29-12.34, P=0.016) were independent risk factors for serious postoperative complications. Conclusion: BMI>30 kg/m², parauterine invasion and preoperative radiotherapy are independent risk factors for intraoperative and postoperative complications.