Abstract:Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) is a special type of rhegmatogenous retinal detachment (RRD), with characteristics of acute onset, rapid development and poor prognosis. At present, there is no definite conclusion about its pathogenesis and mechanism. Recent studies have shown that retinol-binding protein 4 (RBP4) is a novel adipocytokine and can participate in the occurrence and development of RRDCD. This paper systematically concluded papers at home and abroad, and reviewed the correlation between RBP4 and RRDCD.