Research progress on regulatory protein and signaling pathway of heavy ion radiation-induced bystander effects

Abstract:

Radiation-induced bystander effects (RIBE) means that radiated cells transmit the damage effect to the irradiated cells through a certain mechanism and irradiated cells show similar biological damage effects to radiated cells. In recent years, many kinds of regulatory proteins and signaling pathways have been found to be involved in apoptosis, proliferation, cell cycle arrest and other biological effects in the process of heavy ion RIBE. This article reviewed the mechanism of these regulatory proteins and signaling pathways in heavy ion RIBE.