Establishment of infrarenal abdominal aortic pseudoaneurysm model in dogs

Abstract:

Objective：To establish infrarenal abdominal aortic pseudoaneurysm model in dogs for hemodynamic study and to do mor－phologic and hemodynamic assessment. Methods：Fourteen female beagle dogs were selected，seven taking the traditional vein patch to establish pseudoaneurysm were regarded as control group and the other seven taking new ‘pocket’ vein patch to establish pseu－doaneurysm model as experimental group. CT angiography examination was carried out immediately and on 7，14，30 d after the operation. Color Doppler ultrasound was carried out on 7 d after the operation. Morphologic and hemodynamic assessments were made. Results：Experimental animal survival rate was 100%. Local wall expansion rate at immediate postoperative period and at 7，14，30 d after the operation were （6.11±2.38）%，（26.14±7.14）%，（63.42±12.77）%，（88.26±14.42）% in control group while（199.39±14.92）%，（216.83±14.68）%，（239.30±16.75）%，（266.30±16.48）% in experiment group. Wall expansion rates were higher in experiment group than in control group at each observation point，with statistically significant differences. Conclusion：Adopting ‘pocket’ vein patch to establish infrarenal obdominal aortic pseudoaneurysm model in dogs is more in line with the morpho－logical and hemodynamic characteristics of the human pseudoaneurysm.