Expression of Survivin gene in hepatic regeneration tissue of rat after partial hepatectomy

Abstract:

Objective：To investigate the effects and its significance of survivin gene in rat liver regeneration after partial hepatectomy. Methods：Wister rat liver regeneration model of 70% partial hepatectomy was established. The expressions of Survivin and cell cycle-related protein cyclinD1 were detected by immunohistochemistry in liver regeneration rat tissues at different time points. Results：The level of Survivin protein expression was significantly increased during 12~72 h after partial hepatectomy and reached its peak at 48 h after partial hepatectomy. The level of cyclinD1 was upregulated at 12，24，48 h，and 72 h after partial hepatectomy and highly correlated with survivin protein level. Conclusion：The high expression of Survivin protein is significantly correlated with the liver regeneration after partial hepatectomy.