Clinical observation of partial splenic embolization on treating refractory immune thrombocytopenia for children

Abstract:

Objective：To explore the clinical effect of partial splenic embolization（PSE） in treating refractory immune thrombocytope－nia（R-ITP） for children. Methods：26 cases of immune thrombocytopenia for children，which were ineffective with internal medicine，were performed with PSE through Seldinger technique via femoral artery with gelatin sponge by superselective sublobar arterial catheterization. Subsequently，the clinical effect and safety of the treatment on R-ITP for children after PSE were evaluated. Results：After one month the treatment by PSE，the counts of peripheral blood platelet were（287.0±61.7）×109 cells/L，while after two years the treatment by PSE，the counts of peripheral blood platelet were（199.3±15.7）×109 cells/L.There were significant difference in pre－operative and postoperative blood platelet counts.The blood platelet-associated antibodies of the effective cases had gone down，espe－cially，the distinct decline of PAIgG. Clinical symptoms improved obviously，no severe complications occurred in 26 cases. Conclu－sion：As a minimal invasive technique，PSE is a safe and effective method on treating R-ITP for children，it can take the place of operation and retain splenic immune function and has definite clinical value.