Expression of Survivin and MMP-2 in breast carcinoma and their correlation

Abstract:

Objective：To discuss the relationship between and significance of the expressions of Survivin and MMP-2 in carcinogene－sis and progression of breast carcinoma through detection and investigation. Methods：The expressions of Survivin and MMP-2 in 114 cases breast carcinoma tissues were detected by immunohistochemistry SP method.The relationship between Survivin and MMP-2 was analyzed，and their correlations with clinical stage，tumor grade of differentiation，axillary lymph node metastasis，and 5-year disease-free survival were also studied. Results：The positive expression rates of Survivin and MMP-2 in breast carcinoma were 71.05% （81/114） and 75.40% （84/114），respectively，which were significantly higher than those in normal breast tissue.Survivin expression had a positive correlation with MMP-2.Both Survivin and MMP-2 were correlated with the clinical stage，pathology grade，axillary lymph nodes metastasis，and 5-year disease-free survival （P<0.05）. Conclusion：The expressions of Survivin and MMP-2 are significantly correlated with the occurrence and development of breast carcinoma. Detection of these two expressions may be valuable for evaluating the prognosis of breast carcinoma.