Experimental study on hepatic-protective effects of Shuangge Jiecheng Pill in rats of alcoholic fatty liver

Abstract:

Objective：To observe the effects of Shuangge Jiecheng Pill on vigor of ADH，GGT，ALT，AST and hepatic tissue protein（HTP），UA，AKP，organ indexes，fatty degeneration degree and inflammation activity in rats of alcoholic fatty liver，and approach its hepatic protective effects. Methods：The model of alcoholic fatty liver disease rat was induced by intragastric administration. 60 rats were randomly divided into 6 groups: 10 were control group，10 model group，10 tiopronin （TP） group and 30 Shuangge Jiecheng Pill（SG） group with high dose（HD），middle dose（MD） and low dose（LD） respectively. SG group were treated with different dosages of Shuangge Jiecheng Pill（20，10，5 g crude drug/（kg·d） and compared with TP group administrated by tiopronin tablet（40 mg/kg）for 4 weeks. The changes of ADH，GGT，ALT，AST，HTP，UA，AKP，organ indexes，fatty degeneration degree and inflammation activity of the rats in the different experimental groups were observed. Results:Compared with the control group，GGT，ALT，AST，UA，AKP and the liver indexes in the model group were obviously increased（P＜0.05） while ADH，HTP，thoracic gland indexes and the body weights were decreased（P＜0.01） and the pathologic hepatic tissue was seen. After the experiment and compared with the model group，the liver indexes in the TP and SG group of HD，MD and LD were obviously changed（P＜0.01） and fatty degeneration degree and inflam－mation activity were lightened. And the indexes in SG group of HD were changed more obviously（P＜0.01） than those of SG group of MD and LD. Conclusion:Shuangge Jiecheng Pill is an effective method for alcoholic fatty liver disease by promoting the metabolism of alcohol，lessening the accumulation of fat in the liver，relieving the hepatocellular damage and resisting impairments to hepatic pro－tein resulting from alcohol. The effect of SG group of HD is significantly superior to the others.