Expressions of maspin and EIF-5A2 in esophageal squamous cell carcinoma and their clinical significance

Abstract:

Objective:To investigate the expressions of maspin and EIF-5A2 in esophageal squamous cell carcinoma and the clinical significance. Methods：Immunohistochemical SP method was used to detecte the expressions of maspin and EIF-5A2 in 60 esophageal carcinoma tissues. Results：Maspin protein expression in esophageal squamous cell carcinoma tissues had a correlation with histologi－cal differentiation and lymph node metastasis（P<0.05），and EIF-5A2 expression in esophageal squamous cell carcinoma tissues had a correlation with invasion，lymph node metastasis and TNM staging（P<0.05）. Conclusion：The expressive intensity of maspin and EIF-5A2 in esophageal carcmoma tissue may be served as the molecular biological index of evaluating infilitration and metastasis. The combined examination of maspin and EIF-5A2 may be useful for the diagnosis of early esophageal squamous cell carcinoma and e－valuating prognosis in esophageal squamous cell carcinoma.