Correlation of body mass index and lung injury in rat models of acute lung injury

Abstract:

Objective:To investigate the correlation between BMI and lung injury degree in acute lung injury of rats. Methods：A total of 60 male sprague-dawley （SD ）rats were randomly divided into control group（C），Oleic acid-treated group（OA），control-hperlipi－demia（C-H） group，and Oleic acid-hperlipidemia（O-A） group. Acute lung injury was induced by injection of OA，O-A（does，0.15 ml/kg） via intravenous vein. Rats were killed at scheduled time-points and the Lung tissues were removed for lung pathology and determination of wet/dry weight ratio（W/D），nuclear factor-kb（NF-κB） expression，inflammatory cytokines interleukin-1β（IL-1β），and tumor necrosis factor α（TNF-α）. Results：In O-H group，the pathology of lung injury score，IL-1β and TNF-α were significant－ly increased，as compared with the OA group （P＜0.05）. The above lung tissue expression of NF-κB mRNA in O-H group were also significantly increased than OA group. Conclusion:Under the same dose of oleic acid induction，the mRNA and the level of inflam－matory cytokines suggest that BMI levels and lung injury were positively correlated with each other.