Expressions and clinical significances of CD44v6 and receptor of HA mediated motility in gastric carcinoma

Abstract:

Objective：To explore the expressions of CD44v6 and receptor of HA mediated motility（RHAMM） in tissues of gastric carcinoma and their relationship with the clinicopathological features and patients’ prognosis. Methods：The expression levels of CD44v6 and RHAMM in 78 cases of resected gastric carcinoma tissues and 25 cases of normal gastric mucosal tissues were detected by immunohistochemistry method. Results：Both CD44v6 and RHAMM were expressed as brown granules. The positive rate of CD44v6 expression in gastric carcinoma tissues was 64.1%（50/78），which was significantly higher than that of 0% in normal tissues（P<0.05）.The positive rate of RHAMM expression in gastric carcinoma tissues was 66.7%（52/78），significantly higher than that of 12%（3/25） in normal tissues （P<0.05）. There was no correlation between CD44v6 and RHAMM expressions and the sex，age，tumor size and tu－mor differentiation （P>0.05）. However，the expressions of CD44v6 and RHAMM were closely related with the invasion depth and the extent of lymph node metastasis （P<0.05）. Conclusion：Both CD44v6 and RHAMM are highly expressed in gastric carcinoma，which may promote the metastasis of gastric carcinoma cells. The expressions of CD44v6 and RHAMM play an important role in the invasion and metastasis of gastric carcinoma.