Abstract:Objective:To explore the risk factors for coronary heart disease in Chongqing area.Methods：A total of 1 834 consecutive patients who had been diagnosed as coronary heart disease（CHD）（n=1 169) or non-CHD（n=665）by coronary angiography between October 2008 and April 2011 were studied retrospectively.The percentage,level and ratio of each risk factor were analyzed and compared,the correlative factors of CHD were screened by multi-factor logistic regression analysis.Results：1.The percentages of male,family history of CHD,diabetes mellitus（DM）,hypertension,smoking,hyperuricemia and hyperfibrinogenemia were significantly higher in CHD group than those in non-CHD group（all P<0.01）.The levels of age,systolic blood pressure(SBP),pulse pressure(PP),hypertension duration,WBC count,apolipoprotein B（apoB）,serum creatinine（Scr）,blood urea nitrogen（BUN）,serum uric acid(SUA),plasma fibrinogen（FIB）,fasting capillary whole blood glucose,and 2-hour postprandial capillary blood glucose were significantly higher in CHD group than those in non-CHD group（all P<0.01）.The levels of high density lipoprotein cholesterol（HDL-C) and apolipoprotein AI（apoAI）were significantly lower in CHD group compared with those in non-CHD group(all P<0.01).The ratios of TC/HDL-C,TG/HDL-C,LDL-C/HDL-C,apoB/apoAI were significantly higher in CHD group than those in non CHD group（all P<0.01）.There were no significantly differences in obesity,diastolic blood pressure(DBP),triglyceride(TG),total cholesterol（TC）,or low-density lipoprotein cholesterol（LDL-C）between the two groups（P>0.05）.2.The multi-factor Logistic regression analysis showed that all the parameters of male,family history of CHD,DM,hypertension,smoking,hyperfibrinogenemia,age,WBC count and apoB were significantly positively correlated with CHD(β＝0.496,1.149,0.595,0.592,0.953,0.282,0.050,0.155 and 1.488,respectively，all P<0.01),and HDL-C was significantly negatively correlated with CHD（β＝－0.575,P<0.05).Conclusion:1.Male,family history of CHD,diabetes mellitus,hypertension,smoking,hyperfibrinogenemia,age,WBC count,and apoB are significantly positively correlated with CHD in Chongqing area; HDL-C is significantly negatively correlated with CHD.They play an important role in occurrence and progression of coronary heart disease.2.Reducing the level of apoB,increasing the level of HDL-C,controlling DM and hypertension and quitting smoking may be the effective measures to reduce the morbidity and to improve the prognosis of CHD in this area.
