Abstract:Objective:To observe the clinical efficacy of continuous blood purification(CBP) for multiple organ dysfunction syndrome(MODS) induced by urinary sepsis and to discuss its effect on cytokines.Methods:Totally 12 patients with MODS induced by urinary sepsis were treated by continuous venous-venous hemofiltration(CVVH).Vital signs,acute physiology and chronic health evaluation system scores,white blood cell,oxygen partial pressure,liver and kidney functions and levels of cytokines such as TNF-α,IL-1 and IL-8 were measured and compared before and after the treatment.Results:The clinical indicators of patients with MODS were improved significantly after CVVH treatment compared with those before the treatment.The plasma concentrations of TNF-α,IL-1,IL-8 were decreased obviously compared with those before the treatment (P<0.05).Conclusion:CVVH can improve the clinical indicators of MODS induced by urinary sepsis,decrease the cytokines level and to some extent promote the patients’ prognosis.
