Abstract:Objective:To explore the influence of early maternal isolation stress on the epilepsy susceptibility of li-pilocapine and amygdala kindling induced seizures models in infantile rats. Methods:Totally 66 newborn SD rat pups were enrolled and randomly divided into three groups (n=22)：the normal control group, the maternal separating 15 minutes group and the maternal separating 3 hours group. All rats were performed with li-pilocapine and amygdala kindling induced-seizures experiment at 16/18 days after the birth. Results: The latency period of li-pilocapine induced-seizures was obviously shortened and the convulsive threshold of amygdala kindling as well as the stimulating number needed for full kindling were markedly decreased in the maternal separating 3 hours group compared with those in the normal control group at 2～15/17 days after the separation (P<0.05). However, there was no significant difference in the above indicators between the normal control group and the maternal separating 15 minutes group at 2～15/17 days after the separation(P>0.05). Conclusion:The stress of early maternal separating for 3 hours can shorten the latency period of li-pilocapine induced-seizures, decrease the threshold of amygdala kindling and the stimulating number needed for full kindling thus enhance the susceptibility of the two seizure models in infantile rats.
