Preparation and quality evaluation of Dextromethorphan chewing gum drug delivery system

Abstract:

Objective:To select the best prescription for Dextromethorphan (DM) chewing gum preparation and to evaluate its quality. Methods: The DM chewing gum preparation was prepared by tablet press method; the formulation was optimized by orthogonal experiments.Results: The best prescription based on the results of orthogonal experiments was that the proportion of gum base,aspartame,menthol and essence was 90%,3%,0.5% and 0.2%,respectively. Conclusion: DM chewing gum preparation can be successfully formulated and its quality can be guaranteed.