Effects of vascular reconstruction by Paclitaxel-carrying liposome microbubbles combined with low-frequency ultrasound on the liver and kidney function in young rabbits

Abstract:

Objective：To evaluate the effects of vascular reconstruction by Paclitaxel-carrying liposome microbubbles（PLM） combined with low-frequency ultrasound on the liver and kidney function in young rabbits. Methods：Twenty-four young New Zealand rabbits aged （60±15） d were randomly divided into normal group，operation group and intervention group. The iliac artery stenosis model was established by balloon dilatation and the intervention model by PLM combined with low-frequency ultrasound at three weeks after the operation. The changes in the lumen area and tunica media-intima area of the iliac artery were measured at one week after the intervention. The liver and kidney function was tested in all groups. Results：The tunica media-intima area of the iliac artery was magnified in operation group compared with that in normal group（P＜0.05），with disarranged cells and stenosis rate of （80.22±6.7）%. Part of the intima of the iliac artery was thickened in intervention group than in normal group and operation group（P＜0.05），with arranged cells in tunica media and stenosis rate of （16.17±10.45）%. There was no difference in the liver and kidney function among all groups（P ＞0.05）. Conclusion：PLM combined with low-frequency ultrasound can exert intervention effect on the angiostenosis in young rabbits without influencing the liver and kidney function.