Expression and significance of HMGB1 and E-cadherin in ovarian carcinoma

Abstract:

Objective：To explore the expression and clinical significance of high mobility group box-1（HMGB1） and E-cadherin in ovarian carcinoma. Methods：Between May 2008 and January 2011，immunohistochemical SP method was used to detect the expres－sion of HMGB1 and E-cadherin in 75 patients with ovarian carcinoma and 40 normal ovarian tissues and to analyze the clinical pathological significance of HMGB1 and E-cadherin in ovarian carcinoma. Results：The positive expression of E-cadherin was lower in ovarian carcinoma than in normal ovarian tissues（χ2=12.62，P＜0.01）. The positive expression of HMGB1 was higher in ovarian car－cinoma than in normal ovarian tissues（58/75 vs. 4/40， χ2=47.60，P＜0.01）. The expression pattern of HMGB1 and E-cadherin were associated with clinical stage and lymph node metastasis（P<0.05），but not with histological subtypes and histological stages（P ＞0.05）. The expression of HMGB1 was negatively correlated with E-cadherin（r=-0.299，P<0.01） in ovarian cancer. Conclusion：HMGB1 and E-cadherin might play an important role in the carcinogenesis and metastasis of ovarian carcinoma.