Prognosis assessment on cervical intraepithelial neoplasia Ⅱ-Ⅲ with positive margins after LEEP by human papillomavirus genotyping

Abstract:

Objective：To assess the prognosis after loop electrosurgical excision procedure（LEEP） of cervical intraepithelial neopla－siaⅡ-Ⅲ（CINⅡ-Ⅲ） with positive margins by human papillomavirus（HPV） genotyping in order to guide clinical treatment. Meth－ods：Totally 65 cases （9.26%） were found positive margins in 702 cases of CINⅡ-Ⅲ after LEEP. ThinPrep cell test（TCT），colpo－scope and HPV genotype were performed preoperatively and at every 6 months after LEEP. Results：The recurrence rate of positive margins was higher than that of negative margins（P<0.05）. The recurrence was not correlated with HPV subtype，multiple HPV types and lesions grade in incision margins（P ＞0.05）. But the persistence HPV infection was associated with higher recurrence rates at 6 months after the operation（P<0.05）. Conclusion：HPV genotype may help to detect recurrences in CINⅡ-Ⅲ with positive margins after LEEP.