Abstract:objective To investigate the willingness to accept PrEP and its influencing factors among regular sex partners of HIV-infected individuals in Sichuan and Xinjiang province . Methods Face-to-face anonymous questionnaire was conducted to 473 qualified objects by non-randomly sampling method. test was employed to conduct univariate analysis, multivariate analysis was conducted using logistic regression .Results Awareness of PrEP among PAR was not high in Sichuan and Xinjiang province, 85.41% had never heard of PrEP, but reached to 80.34% after being taught on PrEP related knowledges by investigators. Logistic regression showed that the multiple influencing factors of the willingness to accept PrEP among PAR population were nation (Uyghur / Han:OR=2.471,P=0.0093), monthly income levels(<= 1000/1001-3000: OR = 2.046, P =0.0184), whether have sex with spouse within six months (yes / no: OR = 2.263, P = 0.0192), self-awareness of the possibility to be infected with HIV from their spouses (medium possibility/great: OR=0.485,P=0.0651；low possibility/great:OR=0.447,P=0.0273), whether would recommend friends to use PrEP (would / would not: OR = 9.416, P <.0001), the time when the spouse was diagnosed with HIV infection (within three years /one year: OR = 0.478, P = 0.0599; three years ago / within one year: OR = 0.374, P =0 .0094).Conlusion Awareness of PrEP among PAR was not high in Sichuan and Xinjiang province, but with a high rate of willingness to accept, propaganda of PrEP in AIDs intervention should be strengthened in the future thus to improve their awareness of PrEP and their willingness to accept PrEP. In the meanwhile, peer education could be possibly carried out among this population which might be an effective way to promote PrEP.
