Effect of high intensity focused ultrasound on immune function of patients with hilar cholangiocarcinoma

Abstract:

Objective：To observe the effect of high intensity focused ultrasound（HIFU） on immune function of patients with hilar cholangiocarcinoma. Methods：HIFU treatment was performed on 32 patients with hilar cholangiocarcinoma. Tests were carried out to find change of T lymphocyte subsets in peripheral blood（CD3+，CD4+，CD8+），cytoactive rate of NK cells and titer of IgG，IgA and IgM before and after HIFU treatment. Results：After HIFU treatment，cytoactive rate of CD3+，CD4+、NK were obviously heightened，however，that of CD8+ was descended（P<0.05）. Titer of IgG，IgA and IgM was increased obviously（P<0.01）. Conclusion:HIFU posses some ef－fects in adjusting immune damage in cells，overcoming tumor immunity escaping and improving immune function in organism.