Comparsion between two fibrinogen detection methods with ELITE PRO coagulometer

Abstract:

Objective：To evaluate the accuracy of using PT-Fib method to determine fibrinogen（Fib） content in plasma samples with ACL ELITE PRO automatic coagulometer（ELITE PRO） and its correlation with results of Clauss method. Methods：Clauss method and PT-Fib method were used to determine Fib content in 232 plasma fibrinogen samples. Correlation analysis was made to get the confidential range in ELITE PRO when detecting Fib content by PT-Fib method. Results：The coefficient of variation of PT-Fib method was 3.8% in ELITE PRO. When the content of Fib was 1.5-4.5 g/L，there was no significant difference between Clauss method and PT-Fib method and results of the two methods were positively coorelated；when the content of Fib was<1.5 g/L or>4.5 g/L，PT-Fib method results was significant higher than that of Clauss method（P >0.05）. Conclusions：When Fib content is 1.5-4.5 g/L detected by PT-Fib method，the result is reliable and can be directly used in clinical report；when Fib content is<1.5 g/L or＞r 4.5 g/L detected by PT-Fib method，the result is unreliable and shoul be rechecked by Clauss method. Combined use of the two methods can be sim－pler，quicker and more accurate and economical in detecting Fib.